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KMID : 0980720030220010031
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Keimyung Medical Journal
2003 Volume.22 No. 1 p.31 ~ p.40
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Effect of Intravenous Administration of Taurocholate on Hepatic Glyoxalase II Activity in Cholestatic Rats
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Kwak Chun-Sik
Kim You-Hee
Chung Sang-Ho
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Abstract
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The possible mechanisms of decreased glyoxalase Ⅱ (GLO-Ⅱ) activity in cholestatic rat liver was studied. Hepatic GLO-Ⅱ activity was determined from the experimental rats with choledocho-caval shunt (CCS) or bile duct obstruction (BDO). The Michaelis-Menten constant in this hepatic enzyme was also measured. The activity of hepatic GLO-Ⅱ as well as the Vmax value was found to be decreased significantly in both CCS plus taurocholic acid (TCA) injection group, and BDO plus TCA injection group than in each control group such as CCS alone and BDO alone. However, the GLO-Ⅱ activity did not change in both the CCS plus tauroursodeoxycholic acid injection group and the BDO plus tauroursodeoxycholic acid injection group. On the other hand, the Km value of the GLO-Ⅱ did not vary in any experimental groups. Above results suggest that TCA repress the biosynthesis of GLO-II in the liver.
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KEYWORD
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Bile duct obstruction, Choledocho-caval shunt, Glyoxalase Ⅱ, Taurocholic acid, Tauroursodeoxycholic acid
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